POPs vs. Fat: Persistent Organic Pollutant Toxicity Targets and Is Modulated by Adipose Tissue

POPs vs. Fat: Persistent Organic Pollutant Toxicity Targets and Is Modulated by Adipose Tissue

Research over the last decade indicates that adipose (fat) tissue serves as more than an energy depot. The tissue has a dynamic role in maintaining normal carbohydrate and lipid levels as well as in regulating metabolic and other physiologic functions. Persistent organic pollutants (POPs), including certain organochlorine pesticides and numerous industrial chemicals, are highly attracted to lip...

Persistent Organic Pollutants ("POPs")

Strictly speaking, all toxins entering the environment can be regarded as environmental poisons. Certain pollutants can, acting over long periods, harm living organisms even in low concentrations. This means that pollutants that are stable and thus persistent have a great ability to act as environmental poisons. Their stability means not only that their effects are long-lasting, but also that t...

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals--depot differences and dysmetabolism implications.

BACKGROUND The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects on human health. OBJECTIVES To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) adi...

Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants

BACKGROUND Adipose tissue (AT) is involved in several physiological functions, including metabolic regulation, energy storage, and endocrine functions. OBJECTIVES In this review we examined the evidence that an additional function of AT is to modulate persistent organic pollutant (POP) toxicity through several mechanisms. METHODS We reviewed the literature on the interaction of AT with POPs...

Persistence and Bioaccumulation of Persistent Organic Pollutants (POPs)